The impact of continuous positive airway pressure therapy on left atrial function assessed by 2D speckle tracking echocardiography in patients with obstructive sleep apnoea

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Obstructive sleep apnoea (OSA) is associated with left atrium (LA) remodelling and dysfunction, developing even before ventricle (LV) hypertrophy diastolic dysfunction. Two-dimensional speckle-tracking echocardiography (2D-STE) may help to detect subclinical LA dysfunction irreversible cardiac changes. Purpose To evaluate changes geometry function after short term continuous positive airway pressure therapy (CPAP) for OSA using 2D-STE. Methods 47 obese patients aged between 18 65 years old were enrolled in the study. Control group (N=13) consisted healthy subjects who either did not have OSA, or it was mild (apnea/hypopnea index (AHI) 5 – 14/ hour). (N=34) moderate severe (AHI ≥ 15/ Transthoracic 2D STE analysis performed 3 months treatment CPAP, control at a baseline only. Statistical analyses SPSS 27.0 software. The value p<0.05 considered as statistically significant. Results younger, had more female patients, prevalence arterial hypertension lower compared group. All preserved LV EF (>50 %) without significant differences groups. related prevalent (p = 0.023) increased myocardial mass when indexed by height (46.11 (8.23) vs 38.96 (5.9) g/m 2.7, p 0.007). significantly higher diameter (43.58 (8.19) 36.23 (3.08) mm, <0.001), while volume differ (p>0.05). reservoir strain (26.56 (1.38) 31.01 (1.56) %, p<0.001) After CPAP diameter, volume, MMi, conduit contractile change , but decreased improved. (Table 1). Conclusions Our study showed height, together reduced ejection fraction. Short improved patients.